New Digital Application Notes
New Digital Application Notes

Mass Detection Application eBook Cover

Get the Mass Detection Application eBook

This eBook contains key application notes that demonstrate the capability and performance of both the ACQUITY QDa Mass Detector and the BioAccord System with the ACQUITY RDa mass detector for routine biopharmaceutical analyses and monitoring applications.

Together, this compendium of materials is intended as a resource for anyone in biopharmaceutical development, manufacturing and QC who wishes to make greater use of mass data, and who seeks to accelerate time-to-market and fuel greater productivity within their respective organizations.


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Intact Mass Analysis

Application note:
Evaluating BioAccord LC-MS System Performance for Deployment of a Compact,  SmartMS-Enabled Biopharma Solution in Late Stage Development and QC Environment  – Intact Mass Analysis

Proteins/monoclonal antibodies (mAbs)

BioAccord streamlined_hp_intact_mass_analysis

Application Note:

A Platform Method for the Molecular Mass Analysis of the Light Chains and Heavy  Chains of Monoclonal Antibodies using the BioAccord System


Antibody Drug Conjugates (ADCs)

BioAccord sec_lc_ms_cysteine_conjugated_adc

Application Notes:

Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the  BioAccord System

Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the  BioAccord and Nano DSC Systems


BioAccord processing_results_massprep_oligos

Application Notes:

Enabling Routine and Reproducible Intact Mass Analysis When Data Integrity  Matters

An Automated Compliance-Ready LC-MS Workflow for Intact Mass Confirmation and  Purity Analysis of Oligonucleotides

Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety  of Extensively Modified Oligonucleotides

mAb Subunit Analysis

Bio Accord subunit_mass_analysis_ides_digest_standard

Application Notes:

Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column,  IonHance CX-MS pH Concentrates, and BioAccord System

Establishment of a Robust mAb Subunit Product Quality Attribute Monitoring  Method Suitable for Development, Process Monitoring, and QC Release

Analysis of Antibody siRNA Conjugate Using BioAccord System

Released N-Glycan Analysis

BioAccord released_nglycan_analysis

Application Notes:

Released N-linked Glycan Analysis Using the BioAccord System

Increasing Productivity and Confidence for N-linked Glycan Analysis of  Biosimilars Using the BioAccord System

Improving UPLC-FLR-MS N-glycan Analysis of Disulfide-rich Fusion Proteins  Through Optimization of Sample Preparation 

Peptide Mapping/Multi-Attribute Monitoring (MAM)

BioAccord high_sequence_coverage_achieved

Application Notes:

Routine Peptide Mapping Analysis using the BioAccord System

Establishing an Integrated Peptide Attribute Profiling and Monitoring Workflow  for Improved Productivity and Confidence

Evaluating BioAccord System Performance in Late Stage Development and QC  Environment – Peptide Mapping Analysis

Extending the Capabilities of the BioAccord LC-MS System with a streamlined  workflow for compliant-ready Multi-Attribute Method (MAM)

A Streamlined Compliant Ready Workflow for Peptide-Based Multi-Attribute Method  (MAM)

Other Applications

BioAccord LC-MS System for Biopharmaceuticals Hero Shot with Logo Sized

Application Notes:

Application of a Mass Confirmation Workflow for Biotherapeutics Screening

Mass Spectral Effects from Using Ammonium Bicarbonate for Protein IEX-MS

Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and  UPLC-MS

Practical Considerations for Optimizing MS Quality during IEX-MS

Ginseng Compound Screening using the ACQUITY RDa Detector

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